Potassium Hydroxide → HCID 178484023, compound

Participants

Reaction Steps

0.990 g (3.16 mmol) trans-3-{4-[(tert-butoxycarbonyl-methyl-amino)-methyl]-cyclohexyl}-propionic acid methyl ester and 660 mg potassium hydroxide were dissolved in 5.0 ml of ethanol and the reaction mixture heated at reflux for 3 hours. It was then evaporated, subsequently poured into 50 ml of an ice/water mixture, acidified with aqueous hydrochloric acid to pH 5 and extracted 3 times with 50 ml of dichloromethane. The combined dichloromethane phases were dried over magnesium sulfate and evaporated under reduced pressure giving 0.900 g (95%) trans-3-{4-[(tert-butoxycarbonyl-methyl-amino)-methyl]-cyclohexyl}-propionic acid as colorless viscous oil, MS: 299 (M+).

Provenance & Evidence