Methanesulfonyl chloride → HCID 178484029, compound

HRID 967137Notes

Reaction equation

[OH:1][CH2:2][CH2:3][CH2:4][C@H:5]1[CH2:10][CH2:9][C@H:8]([CH2:11][N:12]([CH3:26])[S:13]([C:16]2[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=2)(=[O:15])=[O:14])[CH2:7][CH2:6]1.[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[CH3:26][N:12]([CH2:11][C@H:8]1[CH2:9][CH2:10][C@H:5]([CH2:4][CH2:3][CH2:2][O:1][S:28]([CH3:27])(=[O:30])=[O:29])[CH2:6][CH2:7]1)[S:13]([C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:23])[F:24])=[CH:18][CH:17]=1)(=[O:15])=[O:14]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178484022HCID 178484022, compound

Product 1

HCID 178484029HCID 178484029, compound

Procedure

In analogy to the procedure described in example 3.4, trans-N-[4-(3-hydroxy-propyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide was treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 3-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyl)-propyl ester as colorless solid, MS: 472 (M+).

Sources & evidence

ORD record: ord-a930fbf765a04c80b0ba4c48e85599c3
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953806B2

Reaction notes

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