HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178484019, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chlorophenyl chloroformate | HCID 139059 | — |
| Reactant | HCID 178484021 | HCID 178484021 | — |
| Solvent | Methanol--water (1/1) | HCID 22242641 | — |
| Product | HCID 178484019 | HCID 178484019 | — |
Reaction Steps
In analogy to the sequence described in examples 1.5 and 1.6, trans-[4-(3-hydroxy-propyl)-cyclohexylmethyl]-methyl-carbamic acid tert-butyl ester was treated with hydrogen chloride solution in methanol/water followed by acylation with 4-chlorophenyl chloroformate [Org. Lett. (2000), 2(8), 1049-1051] to yield trans-[4-(3-hydroxy-propyl)-cyclohexylmethyl]-methyl-carbamic acid 4-chloro-phenyl ester as colorless viscous oil, MS: 340 (MH+, 1Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06953806B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-7eb6547e22d64ad38eb066cdb8b598b1 |
| Source note | uspto-grants-2005_10 |