Methanesulfonyl chloride → HCID 178484026, compound

HRID 967139Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:23])[N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][CH2:20][CH2:21][OH:22])[CH2:15][CH2:14]2)[CH3:11])=[CH:4][CH:3]=1.[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]([N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][CH2:20][CH2:21][O:22][S:25]([CH3:24])(=[O:27])=[O:26])[CH2:15][CH2:14]2)[CH3:11])=[O:23])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178484019HCID 178484019, compound

Product 1

HCID 178484026HCID 178484026, compound

Procedure

In analogy to the procedure described in example 3.4, trans-[4-(3-hydroxy-propyl)-cyclohexylmethyl]-methyl-carbamic acid 4-chloro-phenyl ester was treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 3-(4-{[(4-chloro-phenoxycarbonyl)-methyl-amino]-methyl}-cyclohexyl)-propyl ester as colorless solid, MS: 418 (MH+, 1Cl).

Sources & evidence

ORD record: ord-4946f0d771b0460ba17dc09d0ebc4ce0
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953806B2

Reaction notes

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