Methanesulfonyl chloride → HCID 178484037, compound

HRID 967145Notes

Reaction equation

HRID 967145 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:22])[N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][CH2:20][OH:21])[CH2:15][CH2:14]2)[CH3:11])=[CH:4][CH:3]=1.[CH3:23][S:24](Cl)(=[O:26])=[O:25]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]([N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][CH2:20][O:21][S:24]([CH3:23])(=[O:26])=[O:25])[CH2:15][CH2:14]2)[CH3:11])=[O:22])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 178484033HCID 178484033, compound

Product 1

HCID 178484037HCID 178484037, compound

Procedure

In analogy to the procedure described in example 3.4, trans-[4-(2-hydroxy-ethyl)-cyclohexylmethyl]-methyl-carbamic acid 4-chloro-phenyl ester was treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 2-(4-{[(4-chloro-phenoxycarbonyl)-methyl-amino]-methyl}-cyclohexyl)-ethyl ester as colorless viscous oil, MS: 404 (MH+, 1Cl).

Sources & evidence

ORD record
ord-87d89236a64a4b2d8fbe26863cb2a874
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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