4-Trifluoromethyl-benzene sulfochloride → HCID 178484036, compound

HRID 967146Notes

Reaction equation

HRID 967146 reaction equation
[CH3:1][NH:2][CH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][CH2:11][OH:12])[CH2:6][CH2:5]1.[S:13](Cl)([OH:16])(=O)=[O:14].[F:18][C:19]([F:27])([F:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[OH:12][CH2:11][CH2:10][C@H:7]1[CH2:8][CH2:9][C@H:4]([CH2:3][N:2]([CH3:1])[S:13]([C:23]2[CH:24]=[CH:25][C:20]([C:19]([F:27])([F:26])[F:18])=[CH:21][CH:22]=2)(=[O:16])=[O:14])[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 222941704-Trifluoromethyl-benzene sulfochlorideHCID 178484032HCID 178484032, compound

Product 1

HCID 178484036HCID 178484036, compound

Procedure

In analogy to the procedure described in example 1.6, trans-2-(4-methylaminomethyl-cyclohexyl)-ethanol was acylated with 4-trifluoromethyl-benzene sulfochloride to yield trans-N-[4-(2-hydroxy-ethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide as colorless solid, MS: 380 (MH+).

Sources & evidence

ORD record
ord-7679e7480e0949edada3236181a9b80e
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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