Methanesulfonyl chloride → HCID 178484038, compound

HRID 967147Notes

Reaction equation

[OH:1][CH2:2][CH2:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([CH2:10][N:11]([CH3:25])[S:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)(=[O:14])=[O:13])[CH2:6][CH2:5]1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[CH3:25][N:11]([CH2:10][C@H:7]1[CH2:8][CH2:9][C@H:4]([CH2:3][CH2:2][O:1][S:27]([CH3:26])(=[O:29])=[O:28])[CH2:5][CH2:6]1)[S:12]([C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:17][CH:16]=1)(=[O:14])=[O:13]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178484036HCID 178484036, compound

Product 1

HCID 178484038HCID 178484038, compound

Procedure

In analogy to the procedure described in example 3.4, trans-N-[4-(2-hydroxy-ethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide was treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 2-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyl)-ethyl ester as colorless solid, MS: 358 (MH+).

Sources & evidence

ORD record: ord-d0b02a5f32f7474999f67982a19e5830
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953806B2

Reaction notes

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