Chloroform → HCID 178479210, compound

Participants

Reaction Steps

A solution of 24.2 g (90.5 mmol) trans-[4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-acetonitrile, of 22 ml (270 mmol) chloroform and of 2.4 g platinum dioxide (Degussa 223) in 250 ml ethanol was stirred at room temperature for 20 hours under a hydrogen atmosphere. The catalyst was then removed by filtration and the solvent evaporated under reduced pressure giving 17.1 g (97.3%) of pure trans-[4-(2-amino-ethyl)-cyclohexyl]-methanol HCl-salt as colorless solid, MS: 158 (MH+).

Provenance & Evidence