反应详情

A suspension of 3.8 g (11.2 mmol) trans-3-{4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl}-(E)-acrylic acid ethyl ester and 400 mg of palladium (10% on carbon) in 40 ml of methanol was stirred for 20 hours at room temperature under a hydrogen atmosphere. The catalyst was removed by filtration and the solvent evaporated under reduced pressure to give 3.67 g of crude trans-3-{4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl}-propionic acid ethyl ester as colorless viscous oil, MS: 359 (MNH4+).

1. customThe catalyst was removed by filtration
2. customthe solvent evaporated under reduced pressure