4-Chlorobenzenesulfonyl chloride → HCID 178483662, compound

HRID 967161Notes

Reaction equation

HRID 967161 reaction equation
Cl.[CH3:2][NH:3][CH2:4][CH2:5][C@H:6]1[CH2:11][CH2:10][C@H:9]([CH2:12][O:13][S:14]([CH3:17])(=[O:16])=[O:15])[CH2:8][CH2:7]1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([S:25]([N:3]([CH3:2])[CH2:4][CH2:5][C@H:6]2[CH2:11][CH2:10][C@H:9]([CH2:12][O:13][S:14]([CH3:17])(=[O:16])=[O:15])[CH2:8][CH2:7]2)(=[O:27])=[O:26])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 178483659HCID 178483659, compound

Product 1

HCID 178483662HCID 178483662, compound

Procedure

In analogy to the procedure described in example 11.15, trans-methanesulfonic acid 4-(2-methylamino-ethyl)-cyclohexylmethyl ester HCl salt was reacted with 4-chloro-benzene sulphonyl chloride to yield trans-methanesulfonic acid 4-{2-[(4-chloro-benzenesulfonyl)-methyl-amino]-ethyl}-cyclohexylmethyl ester as colorless viscous oil, MS: 424 (MH+, 1Cl).

Sources & evidence

ORD record
ord-d2f84ec847494a79bebd324e6f709f01
Source dataset
uspto-grants-2005_10
Patent number
US06953806B2

Reaction notes

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