Aluminium lithium hydride → HCID 178484123, compound

Participants

Reaction Conditions

Reaction Steps

2.2 g (6.88 mmol) trans-4-(4-benzyloxy-butoxy)-cyclohexanecarboxylic acid methylamide dissolved in 10 ml of tetrahydrofuran were added slowly to a suspension of 0.261 g of lithium aluminium hydride in 10 ml of tetrahydrofuran. The reaction mixture was then stirred at 50° C. for 2 hours, cooled to 0° C., treated with 2 g of ice, stirred at room temperature for 30 minutes, diluted with ethyl acetate, dried over sodium sulfate, filtered and evaporated to give 2.05 g (97.4%) trans-[4-(4-benzyloxy-butoxy)-cyclohexylmethyl]-methyl-amine as light brown viscous oil, MS: 306 (MH+).

Provenance & Evidence