Methanesulfonyl chloride → HCID 178484126, compound

HRID 967166Notes

Reaction equation

[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([CH2:13][N:14]([CH3:28])[S:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]([F:27])([F:26])[F:25])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[CH2:9][CH2:8]1.[CH3:29][S:30](Cl)(=[O:32])=[O:31]>>[CH3:28][N:14]([CH2:13][C@H:10]1[CH2:11][CH2:12][C@H:7]([O:6][CH2:5][CH2:4][CH2:3][CH2:2][O:1][S:30]([CH3:29])(=[O:32])=[O:31])[CH2:8][CH2:9]1)[S:15]([C:18]1[CH:19]=[CH:20][C:21]([C:24]([F:27])([F:25])[F:26])=[CH:22][CH:23]=1)(=[O:16])=[O:17]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178484120HCID 178484120, compound

Product 1

HCID 178484126HCID 178484126, compound

Procedure

In analogy to the procedure described in example 3.4, trans-N-[4-(4-hydroxy-butoxy)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide was treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 4-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyloxy)-butyl ester as colorless solid, MS: 502 (M+).

Sources & evidence

ORD record: ord-fea0d3b9ef304b2b896dd96872d56982
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953806B2

Reaction notes

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