Methanesulfonyl chloride → HCID 178484125, compound

HRID 967169Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:25])[N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][OH:24])[CH2:15][CH2:14]2)[CH3:11])=[CH:4][CH:3]=1.[CH3:26][S:27](Cl)(=[O:29])=[O:28]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C:9]([N:10]([CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([O:19][CH2:20][CH2:21][CH2:22][CH2:23][O:24][S:27]([CH3:26])(=[O:29])=[O:28])[CH2:15][CH2:14]2)[CH3:11])=[O:25])=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 178484117HCID 178484117, compound

Product 1

HCID 178484125HCID 178484125, compound

Procedure

In analogy to the procedure described in example 3.4, trans-[4-(4-hydroxy-butoxy)-cyclohexylmethyl]-methyl-carbamic acid 4-chloro-phenyl ester was treated with methanesulfonyl chloride to yield trans-methanesulfonic acid 4-(4-{[(4-chloro-phenoxy-carbonyl)-methyl-amino]-methyl}-cyclohexyloxy)-butyl ester as colorless viscous, MS: 448 (MH+, 1 Cl).

Sources & evidence

ORD record: ord-fb318389c6a64d07b36e1df18f089b19
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06953806B2

Reaction notes

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