HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 178484118, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Di-tert-butyl dicarbonate | HCID 90495 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Methylamide | HCID 21952893 | — |
| Reactant | HCID 178501286 | HCID 178501286 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | HCID 178484118 | HCID 178484118 | — |
Reaction Steps
In analogy to the sequence described in examples 15.6, 15.7, 15.8, 15.9 and 15.10, cis-4-(4-benzyloxy-butoxy)-cyclohexanecarboxylic acid methyl ester (example 15.5) was hydrolysed with sodium hydroxide in water/dioxane, then, the acid formed was converted into its N-methyl-amide, which was reduced with lithium aluminium hydride, treated with di-tert-butyl-dicarbonate and hydrogenated giving cis-[4-(4-hydroxy-butoxy)-cyclohexyl-methyl]-methyl-carbamic acid tert-butyl ester as colorless viscous oil, MS: 316 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06953806B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-4cd18c773b4b4056979089c7cacab1f6 |
| Source note | uspto-grants-2005_10 |