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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 967187Generated: November 1, 2026

1,4-Dibromobutane → HCID 178484054, compound

https://huagongshe.com/reaction/967187

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DibromobutaneHCID 8056—
ReactantHCID 178484051HCID 178484051—
CatalystTetrabutylammonium hydrogen sulfateHCID 94433—
SolventDichloromethaneHCID 6344—
SolventSodium HydroxideHCID 14798—
ProductHCID 178484054HCID 178484054—

Reaction Steps

In analogy to the method described in example 19.1, trans-N-(4-hydroxymethyl-cyclohexylmethyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide (example 5.1) was reacted with 1,4-dibromo-butane in dichloromethane and aqueous sodium hydroxide solution in the presence of tetrabutylammonium hydrogensulfate to yield trans-N-[4-(4-bromo-butoxymethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide as colorless solid, MS: 500 (MH+, 1Br).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06953806B2
Source datasetuspto-grants-2005_10
ORD IDord-6d8ebbec0fcb4be1b39af97aa036f902
Source noteuspto-grants-2005_10