Aluminium lithium hydride → HCID 178483640, compound

Participants

Reaction Steps

800 mg (21 mmol) of lithium aluminium hydride were added within 10 minutes to a solution of 4.5 g (15.87 mmol) crude trans-methyl-{2-[4-(2-oxo-ethyl)-cyclohexyl]-ethyl}-carbamic acid tert-butyl ester in 40 ml of tetrahydrofuran. After stirring for 3 hours at room temperature, 40 ml of brine was dropped carefully into the reaction mixture. The reaction mixture was stirred for another 20 minutes at room temperature and then partitioned between ether, 1N HCl and water. After drying of the ether phase over sodium sulfate and concentration under reduced pressure, 4.26 g of trans-{2-[4-(2-hydroxy-ethyl)-cyclohexyl]-ethyl}-methyl-carbamic acid tert-butyl ester was obtained, which was used without further purification.

Provenance & Evidence