Methanesulfonyl chloride → HCID 178483643, compound

Participants

Reaction Steps

In analogy to the procedures described in examples 11.13, 11.14 and 11.15, trans-{2-[4-(2-hydroxy-ethyl)-cyclohexyl]-ethyl}-methyl-carbamic acid tert-butyl ester was reacted with methanesulfonyl chloride to give trans-methanesulfonic acid 2-{4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl}-ethyl ester, which was subsequently treated with 4N hydrogen chloride in dioxan to yield trans-methanesulfonic acid 2-[4-(2-methylamino-ethyl)-cyclohexyl]-ethyl ester HCl salt as colorless solid; treatment of the trans-methanesulfonic acid 2-[4-(2-methylamino-ethyl)-cyclohexyl]-ethyl ester HCl salt with 4-chloro-benzene sulphonyl chloride then yielded trans-methanesulfonic acid 2-(4-{2-[(4-chloro-benzenesulfonyl)-methyl-amino]-ethyl}-cyclohexyl)-ethyl ester as colorless oil, MS: 438 (MH+, 1Cl).

Provenance & Evidence