HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → HCID 178484031, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 178484038 | HCID 178484038 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178484031 | HCID 178484031 | — |
Reaction Steps
In analogy to the procedure described in example 25.1, trans-methanesulfonic acid 2-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyl)-ethyl ester (example 9.10) was reacted with imidazole in N,N-dimethylformamide in the presence of sodium hydride to yield trans-N-[4-(2-imidazol-1-yl-ethyl)-cyclohexylmethyl]-N-methyl-4-trifluoromethyl-benzenesulfonamide as yellowish solid, MS: 430 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06953806B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-3d6a05e5abe640b8b634982e862d22cb |
| Source note | uspto-grants-2005_10 |