4-Chlorothieno[2,3-d]pyrimidine → HCID 10128333, compound

HRID 967318Notes

Reaction equation

HRID 967318 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][S:8][C:4]=2[N:5]=[CH:6][N:7]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:21]2[C@@H:30]3[C@@H:25]([CH2:26][CH:27]=[CH:28][CH2:29]3)[C:24](=[O:31])[N:23]([CH:32]3[CH2:37][CH2:36][N:35](C4C=CC([N+]([O-])=O)=CC=4)[CH2:34][CH2:33]3)[N:22]=2)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]>O>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([C:21]2[C@@H:30]3[C@@H:25]([CH2:26][CH:27]=[CH:28][CH2:29]3)[C:24](=[O:31])[N:23]([CH:32]3[CH2:37][CH2:36][N:35]([C:2]4[C:3]5[CH:10]=[CH:9][S:8][C:4]=5[N:5]=[CH:6][N:7]=4)[CH2:34][CH2:33]3)[N:22]=2)[CH:16]=[CH:17][C:18]=1[O:19][CH3:20]

Participants

4

Reactant 2

HCID 7366184-Chlorothieno[2,3-d]pyrimidineHCID 10128150HCID 10128150, compound

Product 1

HCID 10128333HCID 10128333, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Prepared from 4-Chloro-thieno[2,3-d]pyrimidine and starting compound A1 as described for compound 11. After the addition of water, the mixture is extracted with diethyl ether. The ether solution is dried over magnesium sulfate. After the addition of a saturated solution of hydrochloric acid in ether, the compound precipitates. M. p. 219-220° C.

Workup

  1. extractionthe mixture is extracted with diethyl ether
  2. dry with materialThe ether solution is dried over magnesium sulfate
  3. additionAfter the addition of a saturated solution of hydrochloric acid in ether
  4. customthe compound precipitates

Sources & evidence

ORD record
ord-00f0b7fa9a3b49c7b4196049feb5668c
Source dataset
uspto-grants-2005_10
Patent number
US06953853B2

Reaction notes

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