Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → (4aS,8aR)-4-(3,4-Dimethoxy-phenyl)-2-piperidin-4-yl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-Phenethylamine, (-)- | HCID 75818 | — |
| 반응물 | cis-2-(3,4-Dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid | HCID 11087524 | — |
| 반응물 | 2,6-Dichloro-3-fluoroacetophenone | HCID 22311317 | — |
| 용매 | 1-Propanol | HCID 1031 | — |
| 생성물 | (4aS,8aR)-4-(3,4-Dimethoxy-phenyl)-2-piperidin-4-yl-4a,5,8,8a-tetrahydro-2H-phthalazin-1-one hydrochloride | HCID 68878851 | — |
반응 단계
A solution of 50 mmol of the salt of (S)-(−)-α-methylbenzylamine and (cis)-2-(3,4-dimethoxybenzoyl)-1,2,3,6-tetrahydrobenzoic acid (starting compound A8), 55 mmol of piperidin-4-yl-hydrazine dihydrochloride and 100 mmol of triethylamine in 150 ml of 1-propanol is refluxed for 18 h. After cooling to RT, the precipitate is filtered off and dried. M. p. 285-288° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06953853B2 |
| 출처 데이터셋 | uspto-grants-2005_10 |
| ORD ID | ord-d9119b8d08b24972b7544871b665b1d5 |
| 출처 메모 | uspto-grants-2005_10 |