tert-Butyl carbazate → Tert-butyl 4-[(tert-butoxycarbonyl)hydrazono]piperidine-1-carboxylate

HRID 967330Notes

Reaction equation

HRID 967330 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:15]([O:19][C:20](=[O:23])[NH:21][NH2:22])([CH3:18])([CH3:17])[CH3:16]>CCCCCC>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=[N:22][NH:21][C:20]([O:19][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:23])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 70091tert-Butyl carbazateHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 20824233Tert-butyl 4-[(tert-butoxycarbonyl)hydrazono]piperidine-1-carboxylate

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A mixture of 0.15 mole of 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (commercially available) and 0.15 mole of tert-butylcarbazate in 250 ml of hexane is stirred for 18 h at RT. The precipitate is filtered off and dried under vacuum. M. p. 172-174° C.

Workup

  1. filtrationThe precipitate is filtered off
  2. customdried under vacuum

Sources & evidence

ORD record
ord-6574a44586a443099e6abafa08b91478
Source dataset
uspto-grants-2005_10
Patent number
US06953853B2

Reaction notes

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