Trifluoroacetic acid → HCID 22293620, compound

Participants

Reaction Steps

To a stirred solution of 10.0 g (26.4 mmol) of the 3-(4-bromo-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester in CH2Cl2 (26.0 mL) was added 26.0 mL of TFA. The resulting mixture was allowed to stir overnight. The solvent was removed under reduced pressure and the solid was dried in vacuo. The dried solid was suspended in Et2O and stirred vigorously for 2 h and then filtered and dried in vacuo to give 10.1 g of a white solid, which was used without further purification. TLC (silica, 10% MeOH/CH2Cl2): Rf=0.05. MS (electrospray): m/z calculated for C12H12BrN3 [M++H] 278.02, observed 278.0.

Provenance & Evidence