HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 967437Generated: October 31, 2026
Methanol → Methyl 3-hydroxy-4-methoxybenzoate
https://huagongshe.com/reaction/967437
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Isovanillic Acid | HCID 12575 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Product | Methyl 3-hydroxy-4-methoxybenzoate | HCID 4056967 | — |
Reaction Steps
10 ml of thionyl chloride was added to 250 ml of MeOH at 0° C. The solution was stirred for 10 min. and 25 g of 3-hydroxy-4-methoxybenzoic acid was added. The reaction was stirred for 16 h at RT then heated to 50° C. for 3 h. The solvents were removed under reduced pressure. The residue was directly used in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06953857B2 |
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| Source dataset | uspto-grants-2005_10 |
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| ORD ID | ord-eb9e5cc689694dfa9e265fb9408b9f95 |
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| Source note | uspto-grants-2005_10 |
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