HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2,4-Dichlorophenylacetic acid → 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2,4-Dichlorophenylacetic acid | HCID 88209 | — |
| Edukt | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| Edukt | Methyl 3-Amino-4-methoxybenzoate | HCID 2734814 | — |
| Katalysator | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 3-[2-(2,4-Dichloro-phenyl)-acetylamino]-4-methoxy-benzoic acid methyl ester | HCID 69652265 | — |
Reaktionsschritte
To a solution of 1.1 g 3-Amino-4-methoxy-benzoic acid methyl ester and 1 g (2,4-Dichloro-phenyl)-acetic acid in 15 ml CH2Cl2, 2.7 ml NEt3 and 1.24 g BOP-Cl and 10 mg DMAP were added. After stirring over night the solvent was removed under reduced pressure and the residue directly purified by chromatography on silica with ethyl acetate/heptane 1:5→1:1 to yield the ester as a yellow oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06953857B2 |
| Quelldatensatz | uspto-grants-2005_10 |
| ORD ID | ord-00b00d3ba4a642e998c16e803869c34d |
| Quellennotiz | uspto-grants-2005_10 |