HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → tert-butyl N-[(1-cyanopiperidin-4-yl)methyl]carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | [1-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester | HCID 23396323 | — |
| Product | tert-butyl N-[(1-cyanopiperidin-4-yl)methyl]carbamate | HCID 23396324 | — |
Reaction Steps
[1-(5-Trichloromethyl-[1,2,4]oxadiazol-3-yl)-piperidin-4-ylmethyl]-carbamic acid tert-butyl ester (500 mg, 1.25 mmol) and 30% aqueous trifluoro-acetic acid (5 ml) were stirred for 24 hours at room temperature. The mixture was evaporated and lyophilised. The product contains excess of trifluoro-acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06953857B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-f31815ad11234f149cbc0fc5bffea470 |
| Source note | uspto-grants-2005_10 |