HuagongsheHuagongshe Chemistry Print Report · For research reference only
{3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol → {5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {3-Methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol | HCID 21986356 | — |
| Reactant | ({5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane | HCID 69591148 | — |
| Product | {5-[2,5-Difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl)methanol | HCID 21986329 | — |
Reaction Steps
The title compound was prepared using a method analogous to that used for the preparation of {3-methyl-5-[4-(trifluoromethoxy)phenyl]thien-2-yl}methanol (intermediate 118) using ({5-[2,5-difluoro-4-(trifluoromethyl)phenyl]-3-methylthien-2-yl}methoxy)(triisopropyl)silane (intermediate 119).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07091237B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-05058ab149f7447fac1844993e48d435 |
| Source note | uspto-grants-2006_08 |