HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Benzoate → 3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Benzoate | HCID 7150 | — |
| Reactant | 1-Biphenyl-2-ylmethanamine | HCID 263366 | — |
| Reactant | N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester | HCID 86586062 | — |
| Reactant | (R)-isoserine ethyl ester hydrochloride | HCID 86586063 | — |
| Product | 3-{4-[3-Biphenyl-2-ylmethyl-1-(4-cyclohexylphenyl)ureidomethyl]benzoylamino}-2(R)-hydroxypropionic acid | HCID 10258106 | — |
Reaction Steps
This compound was prepared similarly as described in example 35 from N-chlorocarbamoyl-4-[(4-cyclohexylphenylamino)methyl]benzoic acid methyl ester and biphenyl-2-ylmethylamine followed by hydrolysis of the benzoic acid methyl ester, coupling with (R)-isoserine ethyl ester hydrochloride. Hydrolysis afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06953812B2 |
| Source dataset | uspto-grants-2005_10 |
| ORD ID | ord-2ea6fb38742a4e0eb38897400ba16f29 |
| Source note | uspto-grants-2005_10 |