Nitric Acid → Methyl 5-nitro-2-(trifluoromethoxy)benzoate

HRID 967666Notes

Reaction equation

HRID 967666 reaction equation
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]([F:19])([F:18])[O:7][C:8]1[CH:17]=[CH:16][CH:15]=[CH:14][C:9]=1[C:10]([O:12][CH3:13])=[O:11]>>[CH3:13][O:12][C:10](=[O:11])[C:9]1[CH:14]=[C:15]([N+:1]([O-:4])=[O:2])[CH:16]=[CH:17][C:8]=1[O:7][C:6]([F:5])([F:19])[F:18]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 2775550Methyl 2-(trifluoromethoxy)benzoate

Product 1

HCID 46311174Methyl 5-nitro-2-(trifluoromethoxy)benzoate

Conditions

Temperature
60 °C

Procedure

Fuming nitric acid (5 mL) was cooled on an ice bath. Methyl 2-(trifluoromethoxy)benzoate (5 g, 22.7 mmol) was slowly added within 30 min keeping the temperature below 15° C. The reaction was then stirred at 60° C. for 1 hour and 2 hours at room temperature. The mixture was poured on ice water whereupon an oil separated. The aqueous supernatant was decanted and additional water (50 mL) was added to the oil. After neutralisation with sodium hydrogen carbonate, the mixture was extracted with ethyl acetate (25 mL). The aqueous phase was extracted with ethyl acetate (15 mL) once more. The combined organic phases were washed with saturated sodium chloride (2×15 mL), dried (magnesium sulphate), and concentrated in vacuo to give 5.69 g of 5-nitro-2-trifluoromethoxybenzoic acid methyl ester. 1H NMR (DMSO-d6): δ 3.93 (3H, s), 7.82 (1H, d), 8.58 (1H, d), 8.67 (1H, s); HPLC-MS (method B): m/z: 266; Rt=6.0 min.

Workup

  1. customthe temperature below 15° C
  2. additionThe mixture was poured on ice water whereupon an oil
  3. customseparated
  4. customThe aqueous supernatant was decanted
  5. additionadditional water (50 mL) was added to the oil
  6. extractionAfter neutralisation with sodium hydrogen carbonate, the mixture was extracted with ethyl acetate (25 mL)
  7. extractionThe aqueous phase was extracted with ethyl acetate (15 mL) once more
  8. washThe combined organic phases were washed with saturated sodium chloride (2×15 mL)
  9. dry with materialdried (magnesium sulphate)
  10. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-75b96e56793a47e1a04f1ca10889121d
Source dataset
uspto-grants-2005_10
Patent number
US06953812B2

Reaction notes

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