Lactose monohydrate → (+)-Lactose

HRID 967677Notes

Reaction equation

HRID 967677 reaction equation
O.[OH:2][CH:3]1[O:22][C@H:21]([CH2:23][OH:24])[C@@H:8]([O:9][C@@H:10]2[O:18][C@H:17]([CH2:19][OH:20])[C@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]2[OH:12])[C@H:6]([OH:7])[C@H:4]1[OH:5]>C(Cl)(F)(F)C(Cl)(Cl)F>[OH:2][CH:3]1[O:22][C@H:21]([CH2:23][OH:24])[C@@H:8]([O:9][C@@H:10]2[O:18][C@H:17]([CH2:19][OH:20])[C@H:15]([OH:16])[C@H:13]([OH:14])[C@H:11]2[OH:12])[C@H:6]([OH:7])[C@H:4]1[OH:5]

Participants

3

Reactant 1

HCID 62223Lactose monohydrate

Product 1

HCID 440995(+)-Lactose

Reagents, catalysts & solvents 1

HCID 6428Cfc 113Solvent

Procedure

Micronised lactose monohydrate (50 g) was placed in a cylindrical glass pelletising pan of 160 mm diameter and 80 mm depth, tapering towards entry, with an axial driving spindle mounted on the flat base. The pan was mounted in the driving chuck of an electric motor at 45° to the vertical and run at 30 rpm (peripheral angular velocity=0.25 ms−1). This arrangement gave the required flow pattern in which the powder climbed and then flowed down over a wide region of the flat base of the pan. A coarse liquid spray of CFC-113 (30 ml) was generated with a “Polyspray 2” (Hozelock) spray gun after pressurising the tank initially with 60 actuations of the hand air pump. The pellets were tumbled for 5 minutes in the closed pan and then immediately stored over silica gel.

Workup

  1. customwas mounted in the driving chuck of an electric motor at 45°
  2. customThis arrangement gave the required flow pattern in which the powder

Sources & evidence

ORD record
ord-4326955987644fbc83c291a3b233dda8
Source dataset
uspto-grants-2005_10
Patent number
US06955824B1

Reaction notes

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