HCID 22223261, compound → HCID 86589661, compound

HRID 967695Notes

Reaction equation

HRID 967695 reaction equation
P(CC1N=CC=CN=1)(=O)=O.[P:11]([O:23][CH2:24][C@H:25]1[O:29][C@@H:28]([N:30]2[C:39]3[N:38]=[CH:37][N:36]=[C:34]([NH2:35])[C:33]=3[N:32]=[CH:31]2)[C@H:27]([OH:40])[C@@H:26]1[OH:41])([O:14][P:15]([O:18]P(O)(O)=O)([OH:17])=[O:16])(=[O:13])[OH:12].[NH2:42][C:43]1[C:48]([CH2:49][P:50](=[O:52])=[O:51])=[CH:47][N:46]=[C:45]([CH3:53])[N:44]=1>>[P:11]([O:23][CH2:24][C@H:25]1[O:29][C@@H:28]([N:30]2[C:39]3[N:38]=[CH:37][N:36]=[C:34]([NH2:35])[C:33]=3[N:32]=[CH:31]2)[C@H:27]([OH:40])[C@@H:26]1[OH:41])([O:14][P:15]([OH:17])([OH:18])=[O:16])(=[O:12])[OH:13].[NH2:42][C:43]1[C:48]([CH2:49][P:50]([O:13][P:11]([OH:23])([OH:14])=[O:12])([OH:52])=[O:51])=[CH:47][N:46]=[C:45]([CH3:53])[N:44]=1

Participants

3

Reactant 2

HCID 22223261HCID 22223261, compoundHCID 86589663HCID 86589663, compound

Product 1

HCID 86589661HCID 86589661, compound

Procedure

As noted above, in bacteria and fungi, phosphomethylpyrimidine kinase; (EC 2.7.4.7) catalyzes the reaction of ATP+4-amino-2-methyl-5-phosphomethylpyrimidine to produce ADP+4-amino-2-methyl-5-diphosphomethylpyrimidine; thiamine-phosphate diphosphorylase; (EC 2.5.1.3) catalyzes the reaction of 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate+4-methyl-5-(2-phosphono-oxyethyl)thiazole to produce diphosphate+thiamine monophosphate; (EC 3.1.3.-) catalyzes the reaction of thiamine monophosphate to produce thiamine. The present inventor has first recognized the importance of this distinction in providing a target for inhibition of pathogenic microorganisms.

Sources & evidence

ORD record
ord-d391b1ad58d4465da4439c22f69f4b3d
Source dataset
uspto-grants-2005_10
Patent number
US06955890B2

Reaction notes

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