HCID 66596703, compound → HCID 131725193, compound

HRID 967696Notes

Reaction equation

HRID 967696 reaction equation
[CH3:1][C:2]1[N+:6]([CH2:7][C:8]2[CH:9]=[N:10][C:11]([CH3:15])=[N:12][C:13]=2[NH2:14])=[CH:5][S:4][C:3]=1[CH2:16][CH2:17][OH:18].[P:19]([O-])([O-:22])([O-:21])=[O:20].[OH:24][P:25]([O:28][P:29]([OH:32])([OH:31])=[O:30])(=[O:27])[OH:26].CC1N=C(N)C(CO)=CN=1.CC1N=CSC=1CCOP(O)(O)=O>>[O-:26][P:25]([O:28][P:29]([O-:32])([O-:31])=[O:30])(=[O:24])[O-:27].[CH3:1][C:2]1[N+:6]([CH2:7][C:8]2[C:13]([NH2:14])=[N:12][C:11]([CH3:15])=[N:10][CH:9]=2)=[CH:5][S:4][C:3]=1[CH2:16][CH2:17][O:18][P:19]([OH:22])([OH:21])=[O:20]

Participants

3

Reactant 2

HCID 66596703HCID 66596703, compoundHCID 87912667HCID 87912667, compound

Product 1

HCID 131725193HCID 131725193, compound

Procedure

As noted above, in bacteria and fungi, phosphomethylpyrimidine kinase; (EC 2.7.4.7) catalyzes the reaction of ATP+4-amino-2-methyl-5-phosphomethylpyrimidine to produce ADP+4-amino-2-methyl-5-diphosphomethylpyrimidine; thiamine-phosphate diphosphorylase; (EC 2.5.1.3) catalyzes the reaction of 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate+4-methyl-5-(2-phosphono-oxyethyl)thiazole to produce diphosphate+thiamine monophosphate; (EC 3.1.3.-) catalyzes the reaction of thiamine monophosphate to produce thiamine. The present inventor has first recognized the importance of this distinction in providing a target for inhibition of pathogenic microorganisms.

Sources & evidence

ORD record
ord-870adce4dde6423f9c98f0a73ad7d20b
Source dataset
uspto-grants-2005_10
Patent number
US06955890B2

Reaction notes

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