Ethyl Acetate → HCID 69754678, compound

Participants

Reaction Steps

To a solution of the product from Step C (0.18 g, 1 mmol) and (2-bromo-1 methyl-ethyl)-carbamic acid benzyl ester (0.27 g, 1 mmol) in DMF (2 mL) was added potassium carbonate (0.17 g, 1.2 mmol) and the mixture stirred at 75° for 18 h. Ethyl acetate (20 mL) and water (20 mL) were added to the reaction mixture and the aqueous layer was separated and extracted with ethyl acetate (3×20 mL). The combined extracts were washed with brine (30 mL), dried (MgSO4), and evaporated to a residue that was purified by chromatography (silica, hexane to 15% ethyl acetate in hexane) to give a syrup (0.27 g): APCl/LCMS m/z 374 (M+H)+.

Provenance & Evidence