4-Cyanophenyl isocyanate → HCID 22291147, compound

Participants

Reaction Steps

To DMF solution (2 mL) of 4-piperazinyl-7-(2-piperidylethoxy)quinazoline (from Example 1, Step E, 0.287 g, 0.84 mmol) added DMF solution (2 mL) of 4-cyanophenylisocyanate (0.181 g, 1.26 mmol) and the reaction was stirred at room temperature overnight. The solvent was evaporated and residue purified by RP-EHLC to afford desired product N-(4-cyanophenyl){4-[7-(2-piperidylethoxy)quinazolin-4-yl]piperazinyl}carboxamide as a white solid (200 mg, 50%). MS (ES) 487(M+H)

Provenance & Evidence