HCID 69736872, compound → HCID 69737255, compound

Participants

Reaction Steps

A solution of 6 g of 11-(5-chloropentyl)-estra-4,9-diene-3,17-dione in 100 ml of ethanol is mixed at room temperature with 1 g of palladium on carbon and refluxed under a hydrogen atmosphere for 0.5 hour. Then, the catalyst is filtered off, it is evaporated to the dry state in a vacuum and chromatographed on silica gel with hexane/acetone. 6.2 g of 11-(5-chloropentyl)-3-hydroxy-estra-1,3,5(10)-trien-17-one is obtained.

Provenance & Evidence