1-Benzyl-4-(4-carboxyphenoxymethyl)piperidin-4-ol → 1-Benzyl-4-(4-methoxycarbonylphenoxymethyl)piperidin-4-ol

Participants

Reaction Steps

The compound (0.86 g) obtained in Step 4 was dissolved in methanol (10 mL) and to the solution was added a 2M trimethylsilyidiazomethan-hexane solution (1.3 mL). After completion of the reaction, the residue from which the solvent was removed under reduced pressure was purified by silica gel column chromatography (Chromatorex NH™) (eluent; ethyl acetate:hexane=1:19 to 1:9) to obtain the titled compound (0.8 g) as crystals.

Provenance & Evidence