1-Benzyl-4-(4-methoxycarbonylphenoxymethyl)piperidin-4-ol → 4-(4-Methoxycarbonylphenoxymethyl)piperidin-4-ol

Participants

Reaction Steps

10% palladium on carbon (2.5 g) was added to a methanol solution (200 mL) of the compound (25 g) obtained in Step 5 and the mixture was stirred at room temperature overnight under hydrogen atmosphere. The catalyst was removed by filtration with Celite™ and the filtrate was condensed under reduced pressure to obtain the titled compound (18.7 g) as crystals.

Provenance & Evidence