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The epoxide 3 prepared above was diluted with CH2Cl2 (30 mL), (3-mercaptopropylsulfanyl) acetic acid methyl ester 4 (1.93 g, 10.7 mmol), prepared according to Chem. Pharm. Bull. 28 (2), 1980, 558-566, was added and the solution was cooled to 0° C. Basic alumina (11.9 g) was added and the reaction mixture was warmed to room temperature. After stirring for 18 h the mixture was filtered through celite and concentrated in vacuo. The residue was purified by flash column chromatography (silica gel, 6:1 hex/EtOAc) to yield 3.6 g (80%) of the above titled compound.

1. customprepared
2. additionBasic alumina (11.9 g) was added
3. temperaturethe reaction mixture was warmed to room temperature
4. filtrationwas filtered through celite and
5. concentrationconcentrated in vacuo
6. customThe residue was purified by flash column chromatography (silica gel, 6:1 hex/EtOAc)