Triethylamine → HCID 22291385, compound

Participants

Reaction Steps

To a stirred solution of 2-{4-[4-phenyl-2-(trifluoromethyl)-1H-imidazol-1-yl]phenyl}ethanol (450 mg, 1.35 mmol) and triethylamine (377 μL, 2.70 mmol) in dichloromethane (13 mL) was added methanesulfonyl chloride (126 μL, 1.62 mmol) at ambient temperature. After 1 h, the reaction mixture was partitioned between dichloromethane and water. The aqueous phase was extracted with dichloromethane (3×10 mL) and the combined organic phase was dried (MgSO4) and concentrated under reduced pressure to give the title compound as a brown oil (quant.). MS (EI) m/z 410 [M]+.

Provenance & Evidence