Potassium Iodide → HCID 22291412, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-{4-[4-phenyl-2-(trifluoromethyl)-1H-imidazol-1-yl]phenyl}ethyl methanesulfonate and sodium azide (175 mg, 2.70 mmol) and potassium iodide (224 mg, 1.35 mmol) in DMF (7 mL) was heated at 100° C. for overnight. After cooling, the reaction mixture was partitioned between ethyl acetate (20 mL) and water (10 mL). The aqueous phase was extracted with ethyl acetate (3×10 mL) and the combined organic phase was dried (MgSO4) and concentrated under reduced pressure. Purification by flash column chromatography on silica gel eluting with hexane/ethyl acetate (gradient elution from 10:1 to 4:1) to afford 450 mg (93%) of the title compound as colorless amorphous: MS (EI) m/z 357 [M]+.

Provenance & Evidence