4-Chlorobenzenesulfonamide → HCID 22291358, compound

HRID 967832Notes

Reaction equation

[C:1]1([C:7]2[N:8]=[C:9]([C:30]([F:33])([F:32])[F:31])[N:10]([C:12]3[CH:17]=[CH:16][C:15]([CH2:18][CH2:19][NH:20][C:21](=O)[O:22]C4C=CC=CC=4)=[CH:14][CH:13]=3)[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:34][C:35]1[CH:40]=[CH:39][C:38]([S:41]([NH2:44])(=[O:43])=[O:42])=[CH:37][CH:36]=1>>[Cl:34][C:35]1[CH:36]=[CH:37][C:38]([S:41]([NH:44][C:21]([NH:20][CH2:19][CH2:18][C:15]2[CH:14]=[CH:13][C:12]([N:10]3[CH:11]=[C:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[N:8]=[C:9]3[C:30]([F:31])([F:32])[F:33])=[CH:17][CH:16]=2)=[O:22])(=[O:42])=[O:43])=[CH:39][CH:40]=1

Participants

Reactant 2

HCID 668244-Chlorobenzenesulfonamide

HCID 22291394HCID 22291394, compound

Product 1

HCID 22291358HCID 22291358, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-{4-[4-phenyl-2-(trifluoromethyl)-1H-imidazol-1-yl]phenyl}ethylcarbamate and 4-chlorobenzenesulfonamide. MS (ESI) m/z 549 [M+H]+, 547 [M−H]−, 1 H-NMR (CDCl3) δ 2.92 (2H, t, J=7.3 Hz), 3.40-3.60 (2H, m), 6.60 (1H, br), 7.24-7.45 (7H, m), 7.51 (2H, d, J=9.0 Hz), 7.77 (2H, d, J=9.0 Hz), 7.82 (2H, d, J=6.9 Hz).

Sources & evidence

ORD record: ord-0985581ea5ed441080f77940d73bdd8a
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06956050B2

Reaction notes

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