1-(1,3-Thiazol-2-yl)butan-1-one hydrobromide → tert-butyl 2-{4-[2-ethyl-4-(1,3-thiazol-2-yl)-1H-imidazol-1-yl]phenyl}ethylcarbamate

HRID 967842Notes

Reaction equation

HRID 967842 reaction equation
[C:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=1)(=[NH:4])[CH2:2][CH3:3].Br.[S:23]1[CH:27]=[CH:26][N:25]=[C:24]1[C:28](=O)[CH2:29]CC>>[CH2:2]([C:1]1[N:5]([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=2)[CH:29]=[C:28]([C:24]2[S:23][CH:27]=[CH:26][N:25]=2)[N:4]=1)[CH3:3]

Participants

3

Reactant 2

HCID 222914041-(1,3-Thiazol-2-yl)butan-1-one hydrobromideHCID 178458051HCID 178458051, compound

Product 1

HCID 22291392tert-butyl 2-{4-[2-ethyl-4-(1,3-thiazol-2-yl)-1H-imidazol-1-yl]phenyl}ethylcarbamate

Procedure

The title compound was prepared according to the procedure described in step 4 of Example 26 from tert-butyl 2-[4-(propanimidoylamino)phenyl]ethylcarbamate and 1-(1,3-thiazol-2-yl)butan-1-one hydrobromide. (Helv. Chim. Acta., 1948, 31, 1142). MS (ESI) m/z 399 [M+H]+.

Sources & evidence

ORD record
ord-5cf86f762f584b1abacc503820f3b553
Source dataset
uspto-grants-2005_10
Patent number
US06956050B2

Reaction notes

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