4-Chlorobenzenesulfonamide → HCID 22291354, compound

HRID 967843Notes

Reaction equation

[CH2:1]([C:3]1[N:4]([C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][NH:21][C:22](=[O:30])OC3C=CC=CC=3)=[CH:15][CH:14]=2)[CH:5]=[C:6]([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)[N:7]=1)[CH3:2].[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([S:38]([NH2:41])(=[O:40])=[O:39])=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:33]=[CH:34][C:35]([S:38]([NH:41][C:22]([NH:21][CH2:20][CH2:19][C:16]2[CH:17]=[CH:18][C:13]([N:4]3[CH:5]=[C:6]([C:8]4[S:9][CH:10]=[CH:11][N:12]=4)[N:7]=[C:3]3[CH2:1][CH3:2])=[CH:14][CH:15]=2)=[O:30])(=[O:39])=[O:40])=[CH:36][CH:37]=1

Participants

Reactant 2

HCID 668244-Chlorobenzenesulfonamide

HCID 22291384HCID 22291384, compound

Product 1

HCID 22291354HCID 22291354, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-{4-[2-ethyl-4-(1,3-thiazol-2-yl)-1H-imidazol-1-yl]phenyl}ethylcarbamate and 4-chlorobenzenesulfonamide. MS (ESI) m/z 516 [M+H]+, 514 [M−H]−, 1H-NMR (CDCl3)δ1.22 (3H, t, J=7.5 Hz), 2.69 (2H, q, J=7.5 Hz), 2.88 (2H, t, J=6.8 Hz), 3.49-3.56 (2H, m), 6.64 (1H, br), 7.21-7.30 (4H, m), 7.48 (2H, d, J=8.8 Hz), 7.58 (1H, s), 7.77 (2H, d, J=3.3 Hz), 7.80 (2H, d, J=8.8 Hz)

Sources & evidence

ORD record: ord-6d2cc1936a39450495b80736a3fa49a3
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06956050B2

Reaction notes

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