Water → HCID 21876330, compound

Participants

Reaction Steps

To a stirred suspension of 2-[4-(2-aminoanilino)phenyl]ethanol (1.6 g, 7 mmol) in toluene (70 mL) was added propionyl chloride (1.5 g, 16 mmol) dropwise at 0° C., and the reaction mixture was heated at reflux temperature for 2 h. After cooling, the mixture was poured into water (50 mL) and extracted with ethyl acetate (100 mL). The organic layer was washed with 2N aqueous NaOH (50 mL) and brine (50 mL), then dried (MgSO4). Removal of solvent gave 1.3 g (58%) of the title compound as brown solids: MS (EI) m/z 322 (M+)

Provenance & Evidence