Triphenylphosphine → HCID 21875609, compound

Participants

Reaction Steps

A mixture of 2-[4-(2-ethyl-1H-benzimidazol-1-yl)phenyl]ethanol (914 mg, 3.4 mmol) in TUF (40 mL) was added diethyl azodicarboxylate (DEAD) (1.2 mg, 7 mmol), triphenylphosphine (1.8 g, 7 mmol) and diphenylphosphoryl azide (DPPA) (1.9 g, 7 mmol). The mixture was stirred at room temperature for 4.5 h. After removal of solvent, the residue was purified by flash column chromatography on silica gel eluting with hexane/ethyl acetate (gradient elution from 1:1 to 1:2) to afford 1000 mg (74%) of the title compound as a brown oil: MS (EI) m/z 291 (M+)

Provenance & Evidence