4-Chlorobenzenesulfonamide → HCID 22291400, compound

HRID 967852Notes

Reaction equation

[C:1]([C:5]1[N:6]=[C:7]([CH2:28][CH3:29])[N:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18][C:19](=O)[O:20]C3C=CC=CC=3)=[CH:12][CH:11]=2)[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:30][C:31]1[CH:36]=[CH:35][C:34]([S:37]([NH2:40])(=[O:39])=[O:38])=[CH:33][CH:32]=1>>[C:1]([C:5]1[N:6]=[C:7]([CH2:28][CH3:29])[N:8]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][CH2:17][NH:18][C:19]([NH:40][S:37]([C:34]3[CH:33]=[CH:32][C:31]([Cl:30])=[CH:36][CH:35]=3)(=[O:39])=[O:38])=[O:20])=[CH:12][CH:11]=2)[CH:9]=1)([CH3:3])([CH3:4])[CH3:2]

Participants

Reactant 2

HCID 668244-Chlorobenzenesulfonamide

HCID 22291383HCID 22291383, compound

Product 1

HCID 22291400HCID 22291400, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-[4-(4-tert-butyl-2-ethyl-1H-imidazol-1-yl)phenyl]ethylcarbamate and 4-chlorobenzenesulfonamide. MS (ESI) m/z 489 [M+H]+, 487 [M−H]−, 1H-NMR (CDCl3)δ1.12 (3H, t, J=7.5 Hz), 1.31 (9H, s), 2.62 (2H, q, J=7.5 Hz), 2.84 (2H, t, J=7.0 Hz), 3.45-3.54 (2H, m), 6.48 (1H, br),6.65 (1H, s), 7.17 (2H, d, J=8.5 Hz), 7.24 (2H, d, J=8.5 Hz), 7.43 (2H, d, J=8.4 Hz), 7.82 (2H, d, J=8.8 Hz).

Sources & evidence

ORD record: ord-f63a80cfc04a4cda95f17dfcfbb3d2b5
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06956050B2

Reaction notes

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