4-(Bromoacetyl)benzonitrile → tert-butyl 2-{4-[4-(4-cyanophenyl)-2-ethyl-1H-imidazol-1-yl]phenyl}ethylcarbamate

HRID 967853Notes

Reaction equation

HRID 967853 reaction equation
[C:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=1)(=[NH:4])[CH2:2][CH3:3].Br[CH2:23][C:24]([C:26]1[CH:33]=[CH:32][C:29]([C:30]#[N:31])=[CH:28][CH:27]=1)=O>>[C:30]([C:29]1[CH:32]=[CH:33][C:26]([C:24]2[N:4]=[C:1]([CH2:2][CH3:3])[N:5]([C:6]3[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=3)[CH:23]=2)=[CH:27][CH:28]=1)#[N:31]

Participants

3

Reactant 2

HCID 986544-(Bromoacetyl)benzonitrileHCID 178458051HCID 178458051, compound

Product 1

HCID 22291416tert-butyl 2-{4-[4-(4-cyanophenyl)-2-ethyl-1H-imidazol-1-yl]phenyl}ethylcarbamate

Procedure

The title compound was prepared according to the procedure described in step 4 of Example 26 from tert-butyl 2-[4-(propanimidoylamino)phenyl]ethylcarbamate and 4-(bromoacetyl)benzonitrile: MS (ESI) m/z 417 [M+H]+.

Sources & evidence

ORD record
ord-034fdd5f5e734a00b3ee8e8f06f89d9b
Source dataset
uspto-grants-2005_10
Patent number
US06956050B2

Reaction notes

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