2-Chlorobenzenesulfonamide → HCID 22291367, compound

HRID 967854Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([CH2:32][CH3:33])[N:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C4C=CC=CC=4)=[CH:16][CH:15]=3)[CH:13]=2)=[CH:5][CH:4]=1)#[N:2].[Cl:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[S:41]([NH2:44])(=[O:43])=[O:42]>>[Cl:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=1[S:41]([NH:44][C:23]([NH:22][CH2:21][CH2:20][C:17]1[CH:16]=[CH:15][C:14]([N:12]2[CH:13]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=3)[N:10]=[C:11]2[CH2:32][CH3:33])=[CH:19][CH:18]=1)=[O:24])(=[O:43])=[O:42]

Participants

Reactant 2

HCID 814102-Chlorobenzenesulfonamide

HCID 22291391HCID 22291391, compound

Product 1

HCID 22291367HCID 22291367, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-{4-[4-(4-cyanophenyl)-2-ethyl-1H-imidazol-1-yl]phenyl}ethylcarbamate and 2-chlorobenzenesulfonamide. MS (ESI) m/z 534 [M+H]+, 532 [M−H]−, 1H-NMR (CDCl3)δ1.26 (3H, t, J=7.5 Hz), 2.70 (2H, q, J=7.7 Hz), 2.86 (2H, t, J=7.1 Hz), 3.47-3.55 (2H, m), 6.58 (1H, br), 7.23-7.31 (3H, m), 7.36 (1H, s), 7.41-7.47 (1H, m), 7.57-7.66 (4H, m), 7.89 (2H, d, J=8.6 Hz),8.01 (1H, d, J=8.4 Hz)

Sources & evidence

ORD record: ord-6eb2d0540f474e6e99883c2750e3ac70
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06956050B2

Reaction notes

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