4-Chlorobenzenesulfonamide → HCID 22291382, compound

HRID 967856Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([CH2:32][CH3:33])[N:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C4C=CC=CC=4)=[CH:16][CH:15]=3)[CH:13]=2)=[CH:5][CH:4]=1)#[N:2].[Cl:34][C:35]1[CH:40]=[CH:39][C:38]([S:41]([NH2:44])(=[O:43])=[O:42])=[CH:37][CH:36]=1>>[Cl:34][C:35]1[CH:36]=[CH:37][C:38]([S:41]([NH:44][C:23]([NH:22][CH2:21][CH2:20][C:17]2[CH:16]=[CH:15][C:14]([N:12]3[CH:13]=[C:9]([C:6]4[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=4)[N:10]=[C:11]3[CH2:32][CH3:33])=[CH:19][CH:18]=2)=[O:24])(=[O:42])=[O:43])=[CH:39][CH:40]=1

Participants

Reactant 2

HCID 668244-Chlorobenzenesulfonamide

HCID 22291391HCID 22291391, compound

Product 1

HCID 22291382HCID 22291382, compound

Procedure

The title compound was prepared according to the procedure described in step 2 of Example 18 from phenyl 2-{4-[4-(4-cyanophenyl)-2-ethyl-1H-imidazol-1-yl]phenyl}ethylcarbamate and 4-chlorobenzenesulfonamide. MS (ESI) m/z 534 [M+H]+, 532 [M−H]−, 1H-NMR (CDCl3)δ1.26 (3H, t, J=7.5 Hz), 2.70 (2H, q, J=7.7 Hz), 2.92 (2H, t, J=7.1 Hz), 3.47-3.55 (2H, m), 6.61 (1H, br), 7.27-7.37 (4H, m), 7.50 (2H, d, J=8.8 Hz), 7.64 (2H, d, J=8.6 Hz), 7.77 (2H, d, J=8.6 Hz), 7.89 (2H, d, J=8.6 Hz).

Sources & evidence

ORD record: ord-d5f32323eaf34fe8ae1a0ef2cb23fd4a
Source dataset: uspto-grants-2005_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06956050B2

Reaction notes

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