2-Bromo-1-(6-methylpyridin-2-yl)ethanone hydrobromide → tert-butyl 2-{4-[2-ethyl-4-(6-methylpyridin-2-yl)-1H-imidazol-1-yl]phenyl]ethylcarbamate

HRID 967857Notes

Reaction equation

HRID 967857 reaction equation
[C:1]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=1)(=[NH:4])[CH2:2][CH3:3].Br.Br[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH3:33])[N:28]=1)=O>>[CH2:2]([C:1]1[N:5]([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][CH2:13][NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[CH:8][CH:7]=2)[CH:24]=[C:25]([C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([CH3:33])[N:28]=2)[N:4]=1)[CH3:3]

Participants

3

Reactant 2

HCID 222914172-Bromo-1-(6-methylpyridin-2-yl)ethanone hydrobromideHCID 178458051HCID 178458051, compound

Product 1

HCID 22291410tert-butyl 2-{4-[2-ethyl-4-(6-methylpyridin-2-yl)-1H-imidazol-1-yl]phenyl]ethylcarbamate

Procedure

The title compound was prepared according to the procedure described in step 4 of Example 26 from tert-butyl 2-[4-(propanimidoylamino)phenyl]ethylcarbamate and 2-bromo-1-(6-methylpyridin-2-yl)ethanone hydrobromide (J. Med. Pharm. Chem., 1961, 3, 561). MS (ESI) m/z 407 [M+H]+.

Sources & evidence

ORD record
ord-c58261e162a84863bf76d19c491e46f3
Source dataset
uspto-grants-2005_10
Patent number
US06956050B2

Reaction notes

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