3-(Chloromethyl)benzoyl chloride → HCID 22291052, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 2, N-(5-amino-2-methylphenyl)-3,4-dimethoxybenzamide was reacted with 3-(chloromethyl)benzoyl chloride to give the title compound in 87% yield; NMR Spectrum: (DMSOd6) 2.19 (s, 3H), 3.82 (s, 6H), 4.84 (s, 2H), 7.06 (d, 1H), 7.23 (d, 1H), 7.57 (m, 5H), 7.80 (s, 1H), 7.9 (d, 1H), 8.0 (s, 1H), 9.76 (s, 1H), 10.26 (s, 1H); Mass Spectrum: M+H+ 439.

Provenance & Evidence